Recombinant Lambda Light Chain Antibody

• Description:

  This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkins lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.

• Specifications:

  Immunohistochemistry (FFPE) : 1-2 µg/mL

• UniProt:

  P01701 & P01842

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Recombinant full-length human IGL protein was used as the immunogen for the recombinant Lambda Light Chain antibody.

• Clonality:

  Recombinant Monoclonal

• Isotype:

  IgG

• Clone:

  LLC/3774R

• Type:

  Recombinant

• Applications:

  IHC-P

• Purity:

  Protein A/G affinity

• Format:

  Purified

• Buffer:

  1 mg/ml in 1X PBS; BSA free, sodium azide free

• Reconstitution:

  Aliquot the recombinant Lambda Light Chain antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

• Limitations:

  This recombinant Lambda Light Chain antibody is available for research use only.

• Storage Conditions:

  Aliquot the recombinant Lambda Light Chain antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

• Formulation:

  1 mg/mL in 1X PBS; BSA free, sodium azide free

• Applications Notes:

  Optimal dilution of the recombinant Lambda Light Chain antibody should be determined by the researcher.

• CAS Number:

  9000-83-3

• Location:

  Cell Surface, cytoplasmic and secreted

• Image Legend:

  IHC staining of FFPE human spleen tissue with recombinant Lambda Light Chain antibody (clone LLC/3774R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.