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CD8A Antibody / CD8 alpha

CAT: 0800-V8824SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V8824SAF-100UGSize:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha) . A majority of thymocytes and a subpopulation of mature T cells and NK cell express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4+/CD8-. Anaplastic large cell lymphoma is usually CD4+ and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P01732
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment from the C-terminal cytoplasmic domain of the alpha chain of human CD8 was used as the immunogen for the CD8A antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the CD8A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD8A antibody is available for research use only.
Storage Conditions
Aliquot the CD8A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CD8A antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
IHC staining of FFPE human tonsil tissue with CD8A antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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