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MUC5AC Antibody

CAT: 0800-V8591BTNSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8591BTNSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This MAb recognizes the peptide core of gastric mucin M1 (recently identified as Mucin 5AC) . Its epitope is located in the C-terminal cysteine rich part of the peptide core of MUC5AC. Its epitope is destroyed by beta-mercaptoethanol but not by periodate treatment. This mucin is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 2-4 µg/mL for 30 minutes at RT
UniProt
P98088
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
An M1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le (a-b) patient was used as the immunogen for the biotinylated MUC5AC antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
45M1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Biotin Conjugate
Buffer
1 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the biotinylated MUC5AC antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).
Limitations
This biotinylated MUC5AC antibody is available for research use only.
Storage Conditions
Store the biotinylated MUC5AC antibody at 2-8°C (up to one month) or aliquot and store at -20°C (longer term) .
Formulation
1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the biotinylated MUC5AC antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human gastric carcinoma with biotinylated MUC5AC antibody (clone 45M1) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.
Product Datasheet
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