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MUC5-AC Antibody

CAT: 0800-V2737IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V2737IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mucin 5AC glycoprotein (MUC5AC) is a HMW glycoprotein belonging to the superfamily of mucins. Mucins are produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is a mucus-forming, secreted mucin that is found in normal gastric and tracheo-bronchial mucosa, but absent from normal colon. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2. Together with a panel of antibodies, Anti-MUC5AC may be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary. MUC5AC antibodies may also be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P98088
Host
Mouse
Reactivity
Human
Immunogen
A synthetic peptide of human MUC5AC tandem repeat was used as the immunogen for the MUC5-AC antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SPM488
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the MUC5-AC antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MUC5-AC antibody is available for research use only.
Storage Conditions
Store the MUC5-AC antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC: Formalin-fixed, paraffin-embedded human gastric carcinoma stained with MUC5-AC antibody (SPM488) .

UniProtKB · P98088

Mucin-5AC

MUC5A_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P98088
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MUC5AC
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
MUC-5AC
EC number
—
Processing
Precursor
Secondary accessions
A0A096LPK4, O60460, O76065, Q13792, Q14425, Q658Q1, Q7M4S5, Q8N4M9, Q8WWQ3, Q8WWQ4, Q8WWQ5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CopperMetal-binding

PTM

Disulfide bondGlycoprotein

Domain

RepeatSignal

Cellular component

Secreted

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