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Mesothelin Antibody / MSLN

CAT: 0800-V8529-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8529-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mesothelin is a 40kDa glycosyl-phosphatidylinositol-anchored glycoprotein cleaved from a 69kDa precursor protein. Mesothelin immunoreactivity is high in cancers of the ovary (serous papillary, endometrioid and undifferentiated) and pancreas, with less frequent staining seen in adenocarcinomas of the endometrium, lung and stomach/esophagus. Mesothelin is one of the most sensitive markers for mesothelioma.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q13421
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 273-407 from the human protein was used as the immunogen for the Mesothelin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
MSLN/3384
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Mesothelin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Mesothelin antibody is available for research use only.
Storage Conditions
Store the Mesothelin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Mesothelin antibody should be determined by the researcher.
Location
Cytoplasmic, cell surface, secreted
Image Legend
IHC staining of FFPE human lung mesothelioma with Mesothelin antibody (clone MSLN/3384) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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