ACE Antibody / Angiotensin I Converting Enzyme

ACE Antibody / Angiotensin I Converting Enzyme

• Description: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
• CAS Number: 9007-83-4
• UniProt: P12821
• Host: Mouse
• Immunogen: A portion of amino acids 652-788 from the human protein was used as the immunogen for the ACE antibody.
• Clonality: Monoclonal
• Isotype: IgG2c κ
• Applications: WB, ELISA, IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Store the ACE antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This ACE antibody is available for research use only.