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Cystatin B Antibody

CAT: 0800-V8489SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V8489SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cystatin A (also designated STF1, STFA, stefin A or cystatin AS) and cystatin B (also designated PME, CST6, STFB, CPI-B, stefin B and liver thiol proteinase inhibitor) are thiol protease inhibitors that form complexes with papain and the cathepsins B, H, and L. cystatin A, a cytoplasmic protein, is one of the precursor proteins of the cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. cystatin B protects against intracellular proteases leaking out of lysosomes and is primarily expressed in heart, liver and kidney.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P04080
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human Cystatin B protein was used as the immunogen for the Cystatin B antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CPTC-CSTB-3
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Cystatin B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cystatin B antibody is available for research use only.
Storage Conditions
Store the Cystatin B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Cystatin B antibody should be determined by the researcher.
Location
Cytoplasm and nucleus
Image Legend
IHC staining of FFPE human lung with Cystatin B antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

UniProtKB · P04080

Cystatin-B

CYTB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P04080
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CSTB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

Acetylation

Cellular component

CytoplasmNucleus

Disease

Disease variantEpilepsyNeurodegeneration

Molecular function

Protease inhibitorThiol protease inhibitor

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