OX40 Antibody

CAT: 0800-V8400-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V8400-20UGSize:20 µg
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Description
This MAb recognizes a protein of 43kDa, identified as OX40, which is also known as CD134.OX40 is a type I integral membrane glycoprotein and member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. It is expressed on activated T lymphocytes, hematopoietic precursor cells and fibroblasts. It functions as a T cell co-stimulatory receptor when bound by OX40 Ligand / TNFSF4 that is expressed by antigen presenting cells. OX40 thereby plays roles in T-cell activation as well as the regulation of differentiation, proliferation or apoptosis of normal and malignant lymphoid cells.OX40 is upregulated at the sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P43489
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 59-205 from the human protein was used as the immunogen for the OX40 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
OX40/2721
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the OX40 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This OX40 antibody is available for research use only.
Storage Conditions
Store the OX40 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the OX40 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
IHC staining of FFPE human lymph node with OX40 antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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