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ABCC5 Antibody / MRP5

CAT: 0800-RQ5789Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ5789Size:100 µg
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Description
Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White) . This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9- (2-phosphonylmethoxyethyl) adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
CAS Number
9007-83-4
Specifications
Immunohistochemistry: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
O15440
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein (amino acids K647-D1409) was used as the immunogen for the ABCC5 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
IHC-P, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the ABCC5 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This ABCC5 antibody is available for research use only.
Storage Conditions
After reconstitution, the ABCC5 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ABCC5 antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human breast cancer with ABCC5 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

UniProtKB · O15440

ATP-binding cassette sub-family C member 5

MRP5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15440
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ABCC5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
7.6.2.-, 7.6.2.2
Processing
—
Secondary accessions
B9EIQ2, O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85, Q9UNP5, Q9UQC3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneEndosomeGolgi apparatusMembrane

PTM

GlycoproteinPhosphoprotein

Domain

RepeatTransmembraneTransmembrane helix

Molecular function

Translocase

Biological process

Transport

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