C1QB Antibody / Complement C1q B-Chain

C1QB Antibody / Complement C1q B-Chain

• Description: C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
• CAS Number: 9007-83-4
• UniProt: P02746
• Host: Mouse
• Immunogen: A recombinant human partial protein (amino acids 41-188) was used as the immunogen for this C1QB antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Store the C1QB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This C1QB antibody is available for research use only.