C1QA Antibody / Complement C1q A-Chain

CAT: 0800-V8123-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V8123-100UGSize:100 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C1q, a subcomponent of the classical complement pathway, is composed of nine subunits that mediate classical complement activation and thereby play an important role in the immune response. Six of these subunits are disulfide-linked dimers of chains A and B, while three of these subunits, designated C1q-A through C1q-C, are disulfide-linked dimers of chain C. Each chain contains an N-terminal collagen-like region and a C-terminal C1q globular domain. The presence of receptors for C1q on effector cells modulates its activity, which may be antibody-dependent or independent. Macrophages are the primary source of C1q, while anti-inflammatory drugs as well as cytokines differentially regulate expression of the mRNA as well as the protein. C1q deficiency is associated with lupus erythematosus and glomerulonephritis.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P02745
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human partial protein (amino acids 104-237) was used as the immunogen for the C1QA antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
C1QA/2954
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the C1QA antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This C1QA antibody is available for research use only.
Storage Conditions
Store the C1QA antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the C1QA antibody should be determined by the researcher.
Location
Secreted
Image Legend
IHC staining of FFPE human liver with C1QA antibody. HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

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