MDM2 Antibody

CAT: 0800-V7950SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V7950SAF-100UGSize:100 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MDM2 is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53. It can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. Overexpression of MDM2 protein is detected in a variety of cancers.
CAS Number
9007-83-4
Specifications
ELISA (order BSA-free format for coating), Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
Q00987
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 154-167 were used as the immunogen for the MDM2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
SMP14
Applications
ELISA, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the MDM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This MDM2 antibody is available for research use only.
Storage Conditions
Store the MDM2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the MDM2 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
Western blot testing of human HepG2 cell lysate with MDM2 antibody (clone SMP14) . Predicted molecular weight: ~55 kDa but can be observed at up to ~90 kDa.

Related Products

CatalogName
R31805MDM4 Antibody / MDMX
RQ8281MDMX Antibody / MDM4
RQ4624NONO Antibody / p54nrb Antibody
F53954-0.05MLAntibody
F53954-0.2MLAntibody
F53952-0.05MLAntibody
F53952-0.2MLAntibody
V8674-20UGInhibin alpha Antibody / INHA antibody
V8674SAF-100UGInhibin alpha Antibody / INHA antibody
V8674-100UGInhibin alpha Antibody / INHA antibody

Alternative Products

CatalogName
MBS854147-01MDM2 Antibody

Popular Products