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MDM4 Antibody / MDMX

CAT: 0800-R31805Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31805Size:100 µg
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Description
Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
O15151
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Amino acids KILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQH of human MDM4 were used as the immunogen for the MDM4 antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide
Reconstitution
After reconstitution, the MDM4 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This MDM4 antibody is available for research use only.
Storage Conditions
After reconstitution, the MDM4 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the MDM4 antibody should be determined by the researcher.
Image Legend
Western blot testing of 1) mouse testis and 2) human 22RV1 lysate with MDM4 antibody. Predicted molecular weight ~55 kDa but may be observed at higher molecular weights due to phosphorylation.

UniProtKB · O15151

Protein Mdm4

MDM4_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O15151
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MDM4
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q2M2Y2, Q32SL2, Q6GS18, Q8IV83
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmNucleus

Disease

Disease variant

Ligand

Metal-bindingZinc

PTM

PhosphoproteinUbl conjugation

Domain

Zinc-finger

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