Recombinant Lambda Light Chain Antibody

CAT: 0800-V7878SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
CAT#:0800-V7878SAF-100UGSize:100 µg
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Description
This MAb is specific to lambda light chain of immunoglobulin and shows no cross-reaction with lambda light chain or any of the five heavy chains. In mammals, the two light chains in an antibody are always identical, with only one type of light chain, kappa or lambda. The ratio of Kappa to Lambda is 70:30. However, with the occurrence of multiple myeloma or other B-cell malignancies this ratio is disturbed. Antibody to the lambda light chain is reportedly useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is malignant.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P01701, P01842
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human IGL protein was used as the immunogen for the recombinant Lambda Light Chain antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RLLC/1738
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant Lambda Light Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Lambda Light Chain antibody is available for research use only.
Storage Conditions
Store the recombinant Lambda Light Chain antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the recombinant Lambda Light Chain antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic, secreted
Image Legend
IHC staining of FFPE human spleen with recombinant Lambda Light Chain antibody (clone rLLC/1738) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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