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IgM Heavy Chain Antibody

CAT: 0800-V7866-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7866-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin's lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P01871
Host
Mouse
Reactivity
Human
Immunogen
Heavy chain of human IgM was used as the immunogen for the IgM Heavy Chain antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
R1/69
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the IgM Heavy Chain antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This IgM Heavy Chain antibody is available for research use only.
Storage Conditions
Store the IgM Heavy Chain antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the IgM Heavy Chain antibody should be determined by the researcher.
Image Legend
IHC staining of FFPE human tonsil with IgM Heavy Chain antibody (clone R1/69) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · P01871

Immunoglobulin heavy constant mu

IGHM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01871
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGHM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A075B6N9, A0A0G2JQL4, P04220, P20769
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityImmunity

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneImmunoglobulinMembraneSecreted

PTM

Disulfide bondGlycoprotein

Domain

Immunoglobulin domainTransmembraneTransmembrane helix

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