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Gelsolin Antibody / GSN

CAT: 0800-V7827-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7827-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gelsolin (also known as brevin, Actin-depolymerizing factor or ADF), a proteinof leukocytes, platelets and other cells, severs Actin filaments in thepresence of submicromolar calcium, thereby isolating cytoplasmic Actin gels. It is a calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping) . It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. Defects in GSN are the cause of amyloidosis type 5 (AMYL5) ; also known as familial amyloidosis Finnish type, typically characterized by cranial neuropathy and lattice corneal dystrophy. Severe systemic disease can develop in some individuals causing peripheral polyneuropathy, amyloid cardiomyopathy, and nephrotic syndrome leading to renal failure.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL
UniProt
P06396
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human full-length protein was used as the immunogen for this Gelsolin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CPTC-Gelsolin-1
Applications
WB
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Gelsolin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Gelsolin antibody is available for research use only.
Storage Conditions
Store the Gelsolin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Gelsolin antibody should be determined by the researcher.

UniProtKB · P06396

Gelsolin

GELS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06396
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GSN
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A2A418, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, Q5T0I2, Q8WVV7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondPhosphoprotein

Molecular function

Actin cappingActin-binding

Coding sequence diversity

Alternative initiationAlternative splicing

Cellular component

AmyloidCytoplasmCytoskeletonSecreted

Disease

AmyloidosisCorneal dystrophyDisease variant

Ligand

CalciumMetal-binding

Biological process

Cilium biogenesis/degradation

Domain

RepeatSignal
Product Datasheet
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