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Gelsolin Antibody

CAT: 0800-R31221Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31221Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gelsolin also known as GNS is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. It is one of the most potent members of the actin-severing gelsolin/villin superfamily. The gene was assigned to human chromosome 9q33.2. Gelsolin is also known as brevin, or actin-depolymerizing factor; it is the principal intracellular and extracellular actin-severing protein. Gelsolin and Gc protein together constitute the extracellular actin-scavenger system which prevents the toxic effects of actin release into the extracellular space under circumstances of cell necrosis. It may have therapeutic potential as a mucolytic agent in CF patients. The antiapoptotic activity of Gelsolin seems to prevent a step leading to cytochrome c release from the mitochondria into the cytosol.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, IHC (FFPE) : 0.5-1 µg/mL, Immunocytochemistry: 0.5-1 µg/mL
UniProt
P06396
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amino acids 763-775 (WDDDYWSVDPLDR-human) were used as the immunogen for this Gelsolin antibody (100% rat homology) .
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, ICC
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2.5% BSA and 0.025% sodium azide/thimerosal
Reconstitution
After reconstitution, the Gelsolin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Gelsolin antibody is available for research use only.
Storage Conditions
After reconstitution, the Gelsolin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the Gelsolin antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Western blot testing of 1) human HeLa, 2) (h) THP1, 3) (h) A549, 4) monkey COS-7, 5) (h) Caco-2, 6) (h) K562 and 7) (h) HL-60 lysate with Gelsolin antibody at 0.5ug/ml. Predicted molecular weight ~86 kDa.
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