HER2 Antibody / ErbB2

CAT: 0800-V7735-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V7735-20UGSize:20 µg
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Description
Recognizes a protein of 185kDa, which is identified as c-erbB-2/HER-2/neu. Its epitope is localized in the extracellular domain. C-erbB-2/HER-2 is a member of the EGFR family. This MAb is specific and shows minimal cross-reaction with other members of the EGFR-family. Receptors of this family are located on the plasma membrane and consist of an extracellular ligand-binding domain that is connected to a large intracellular domain by a single transmembrane sequence. c-erbB-2/HER-2 protein is over-expressed in a variety of carcinomas especially those of breast and ovary.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL
UniProt
P04626
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human HER2 protein fragment within amino acids 311-462 was used as the immunogen for the HER2 antibody. Its epitope is localized in the extracellular domain.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ERBB2/3078
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the HER2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This HER2 antibody is available for research use only.
Storage Conditions
Store the HER2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the HER2 antibody should be determined by the researcher.
Location
Cell surface
Image Legend
IHC staining of FFPE human breast carcinoma with HER2 antibody (clone ERBB2/3078) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

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