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FOLH1 Antibody / PSMA

CAT: 0800-V7639SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7639SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. [UniProt]
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q04609
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 232-433 from the human protein was used as the immunogen for this FOLH1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
GCP2-1
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the FOLH1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This FOLH1 antibody is available for research use only.
Storage Conditions
Store the FOLH1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
The stated application concentrations are suggested starting points. Titration of the FOLH1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Location
Cytoplasmic, cell surface
Image Legend
Western blot testing of human LNCaP cell lysate with FOLH1 antibody. Predicted molecular weight ~100 kDa.

UniProtKB · Q04609

Glutamate carboxypeptidase 2

FOLH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04609
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FOLH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.17.21
Processing
—
Secondary accessions
A4UU12, A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8, O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, Q9NYE2, Q9P1P8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

Molecular function

CarboxypeptidaseDipeptidaseHydrolaseMetalloproteaseMultifunctional enzymeProtease

Cellular component

Cell membraneCytoplasmMembrane

PTM

GlycoproteinPhosphoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix
Product Datasheet
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