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FOLH1 Antibody / PSMA

CAT: 0013-GTR18082584-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082584-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Folate hydrolase 1 (FOLH1), also known as Prostate-specific membrane antigen (PSMA), has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. [UniProt]
UniProt
Q04609
Reactivity
Human
Immunogen
A portion of amino acids 232-433 from the human protein was used as the immunogen for this FOLH1 antibody.
Clonality
Monoclonal
Clone
GCP2-1
Conjugation
Unconjugated
Field of Research
Epigenetics
Purification
Protein G affinity chromatography
Dilution
Western blot: 1-2ug/ml, Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
The stated application concentrations are suggested starting points. Titration of the FOLH1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Tested Applications
IHC-P, WB
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG2b, kappa

UniProtKB · Q04609

Glutamate carboxypeptidase 2

FOLH1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04609
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FOLH1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.17.21
Processing
—
Secondary accessions
A4UU12, A9CB79, B7Z312, B7Z343, D3DQS5, E9PDX8, O43748, Q16305, Q541A4, Q8TAY3, Q9NP15, Q9NYE2, Q9P1P8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-bindingZinc

Molecular function

CarboxypeptidaseDipeptidaseHydrolaseMetalloproteaseMultifunctional enzymeProtease

Cellular component

Cell membraneCytoplasmMembrane

PTM

GlycoproteinPhosphoprotein

Domain

Signal-anchorTransmembraneTransmembrane helix

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