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Recombinant CELA3B Antibody / Elastase 3B

CAT: 0800-V7482IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7482IHC-7MLSize:7 mL
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Description
This MAb recognizes a protein of ~30kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B) . Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function.
CAS Number
9000-83-3
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P08861
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein (aa 82-238) was used as the immunogen for the recombinant CELA3B antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CELA3B/2810R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the recombinant CELA3B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant CELA3B antibody is available for research use only.
Storage Conditions
Store the recombinant CELA3B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of human pancreas with recombinant CELA3B antibody (clone CELA3B/2810R) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P08861

Chymotrypsin-like elastase family member 3B

CEL3B_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08861
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CELA3B
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.70
Processing
Precursor
Secondary accessions
B2RE44, P11423, Q5VU28, Q5VU29, Q5VU30
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Domain

Signal

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