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CELA3B Antibody / Elastase 3B

CAT: 0800-V3449SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3449SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This mAb recognizes a protein of ~30 kDa, identified as CELA3B (Chymotrypsin like elastase family member 3B), or Elastase 3B. Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six genes which encode the structurally similar proteins: Elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, 3B has little elastolytic activity. Like most of the human elastases, 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein; it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. It may also function in the intestinal transport and metabolism of cholesterol. Elastases 3A/B have been referred to as Protease E and as Elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays.
CAS Number
9007-83-4
Specifications
ELISA: 2-4 µg/mL (order BSA/azide-free format), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08861
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein (aa 82-238) was used as the immunogen for the CELA3B antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
CELA3B/1757
Applications
ELISA, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the CELA3B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CELA3B antibody is available for research use only.
Storage Conditions
Store the CELA3B antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CELA3B antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC testing of human pancreas with CELA3B antibody (clone CELA3B/1757) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9, for 10-20 min followed by cooling at RT for 20 min.
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