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Recombinant Desmin Antibody

CAT: 0800-V7478-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7478-20UGSize:20 µg
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Description
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain alpha-helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P17661
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the recombinant Desmin antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
DES/2960R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the recombinant Desmin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Desmin antibody is available for research use only.
Storage Conditions
Store the recombinant Desmin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human skeletal muscle with recombinant Desmin antibody (clone DES/2960R) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9 for 10-20 min and allow to cool before testing.

UniProtKB · P17661

Desmin

DESM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17661
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DES
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q15787, Q549R7, Q549R8, Q549R9, Q8IZR1, Q8IZR6, Q8NES2, Q8NEU6, Q8TAC4, Q8TCX2, Q8TD99, Q9UHN5, Q9UJ80
Protein keywords

PTM

ADP-ribosylationMethylationPhosphoproteinUbl conjugation

Disease

CardiomyopathyDesmin-related myopathyDisease variantLimb-girdle muscular dystrophyMyofibrillar myopathy

Cellular component

Cell membraneCytoplasmIntermediate filamentMembraneNucleus

Domain

Coiled coil

Molecular function

Muscle protein

Technical term

Proteomics identificationReference proteome

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