Desmin Antibody

CAT: 0800-V3195-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V3195-20UGSize:20 µg
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Description
Cytoskeletal intermediate filaments (IFs) constitute a diverse group of proteins that are expressed in a highly tissue-specific manner. IFs are constructed from two-chain α -helical coiled-coil molecules arranged on an imperfect helical lattice, and have been widely used as markers for distinguishing individual cell types within a tissue and identifying the origins of metastatic tumors. Vimentin is an IF general marker of cells originating in the mesenchyme. Vimentin and Desmin, a related class III IF, are both expressed during skeletal muscle development. Desmin, a 469 amino acid protein found near the Z line in sarcomeres, is expressed more frequently in adult differentiated state tissues. Anti-desmin detects cells of normal smooth, skeletal, and cardiac muscles. Antibody reacts with leiomyomas, leiomyosarcoma, rhabdomyomas, rhabdomyosarcoma, and perivascular cells of glomus tumors of the skin.
CAS Number
9007-83-4
Specifications
Immunofluorescence: 1-2 µg/mL, Flow cytometry: 0.5-1ug/10^6 cells, Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P17661
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant human Desmin was used as the immunogen for the Desmin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
DES/1711
Applications
IF, FACS, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Desmin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Desmin antibody is available for research use only.
Storage Conditions
Store the Desmin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Desmin antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human uterus with Desmin antibody (clone DES/1711) . Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.

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