GSTM2 Antibody

CAT: 0800-V7416-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V7416-20UGSize:20 µg
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Description
Members of the glutathione S-transferase (GST) family of proteins function in the detoxification of xenobiotics to protect cells against toxicant-induced damage. There are eight families of GST proteins, each of which are composed of proteins that have a variety of functions throughout the cell. The GSTM proteins (GSTM1-GSTM5 in human and GSTM1-GSTM7 in mouse) are members of the mu class of enzymes that conjugate with glutathione and function in the detoxification of carcinogens, environmental toxins and products of oxidative stress. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Null mutations of this class mu gene have been linked with an increase in a number of cancers, likely due to an increased susceptibility to environmental toxins and carcinogens. Multiple protein isoforms are encoded by transcript variants of this gene. GSTM2 is specific for muscle hence the alternate name GST muscle antibody.
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 0.5-1 µg/mL for 30 min at RT
UniProt
P28161
Host
Mouse
Reactivity
Human
Immunogen
Full length recombinant human protein was used as the immunogen for this GSTM2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CPTC-GSTMu2-2
Applications
FACS, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the GSTM2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This GSTM2 antibody is available for research use only.
Storage Conditions
Store the GSTM2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cytoplasmic
Image Legend
Immunofluorescent staining of fixed and permeabilized human HeLa cells with GSTM2 antibody (green) and Reddot nuclear stain (red) .
Product Datasheet
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