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Recombinant Bcl6 Antibody

CAT: 0800-V7350-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7350-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Bcl6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation which has different mechanisms of action specific to the lineage and biological functions. Forms complexes with different corepressors and histone deacetylases to repress the transcriptional expression of different subsets of target genes. Represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' (BCL6-binding site) or indirectly by repressing the transcriptional activity of transcription factors. In GC B-cells, represses genes that function in differentiation, inflammation, apoptosis and cell cycle control, also autoregulates its transcriptional expression and up-regulates, indirectly, the expression of some genes important for GC reactions, such as AICDA, through the repression of microRNAs expression, like miR155. [UniProt]
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P41182
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 256-389 were used as the immunogen for the recombinant Bcl6 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
ARBC6-2R
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the recombinant Bcl6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant Bcl6 antibody is available for research use only.
Storage Conditions
Store the recombinant Bcl6 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear
Image Legend
IHC testing of FFPE human tonsil with recombinant Bcl6 antibody (clone ARBC6-2R) . Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min.

UniProtKB · P41182

B-cell lymphoma 6 protein

BCL6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P41182
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BCL6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
BCL-6
EC number
—
Processing
—
Secondary accessions
A7E241, B8PSA7, D3DNV5
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative splicingChromosomal rearrangement

Biological process

ImmunityInflammatory responseTranscriptionTranscription regulation

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Disease

Proto-oncogene

Domain

RepeatZinc-finger

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