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PMEPA1 Antibody / TMEPAI

CAT: 0800-V7347-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7347-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PMEPA1 (prostate transmembrane protein, androgen induced 1), or TMEPAI (Transmembrane prostate androgen induced protein) is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1 interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of PMEPA1 is observed in prostate tumors, suggesting that PMEPA1 may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
Q969W9
Host
Mouse
Reactivity
Human
Immunogen
Full-length recombinant human protein was used as the immunogen for the PMEPA1 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
PTAI1-1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the PMEPA1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This PMEPA1 antibody is available for research use only.
Storage Conditions
Store the PMEPA1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell surface, cytoplasm
Image Legend
IHC staining of FFPE human prostate carcinoma with PMEPA1 antibody (clone PTAI1-1) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min and allow to cool before testing.

UniProtKB · Q969W9

Protein TMEPAI

PMEPA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q969W9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PMEPA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5TDR6, Q8NER4, Q96B72, Q9UJD3
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

EndosomeGolgi apparatusMembrane

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

Molecular function

Signal transduction inhibitor

Biological process

Ubl conjugation pathway

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