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TMEPAI Antibody / PMEPA1

CAT: 0800-V7329IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7329IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PMEPA1 (prostate transmembrane protein, androgen induced 1), or TMEPAI (Transmembrane prostate androgen induced protein) is a 287 amino acid single-pass membrane protein that contains WW-binding motifs and localizes to the cell membrane. Expressed at high levels in prostate, kidney and ovary, PMEPA1/TMEPAI interacts with NEDD4 and may play a role in regulating AR (androgen receptor) levels, specifically in prostate cells. Down regulation of TMEPAI is observed in prostate tumors, suggesting that TMEPAI may exhibit activity as a tumor suppressor. Overexpression of this protein may play a role in multiple types of cancer.
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
Q969W9
Host
Mouse
Reactivity
Human
Immunogen
Full-length recombinant human protein was used as the immunogen for the TMEPAI antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PMEPA1/2698
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the TMEPAI antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This TMEPAI antibody is available for research use only.
Storage Conditions
Store the TMEPAI antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cell surface, cytoplasm
Image Legend
IHC staining of FFPE human prostate carcinoma with TMEPAI antibody (clone PMEPA1/2698) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min and allow to cool before testing.

UniProtKB · Q969W9

Protein TMEPAI

PMEPA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q969W9
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PMEPA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q5TDR6, Q8NER4, Q96B72, Q9UJD3
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

EndosomeGolgi apparatusMembrane

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

Molecular function

Signal transduction inhibitor

Biological process

Ubl conjugation pathway

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