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Recombinant DOG1 Antibody

CAT: 0800-V7326-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V7326-20UGSize:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Expression of DOG-1 protein is elevated in the gastrointestinal stromal tumors (GIST's), c-kit signaling-driven mesenchymal tumors of the GI tract. DOG-1 is rarely expressed in other soft tissue tumors, which, due to appearance, may be difficult to diagnose. Immunoreactivity for DOG-1 has been reported in 97.8 percent of scorable GIST's, including all c-kit negative GIST's. Overexpression of DOG-1 has been suggested to aid in the identification of GISTs, including Platelet-Derived Growth Factor Receptor Alpha mutants that fail to express c-kit antigen. The overall sensitivity of DOG1 and c-kit in GIST's is nearly identical: 94.4% vs. 94.7%.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q5XXA6
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 2-101 from the human protein was used as the immunogen for this recombinant DOG1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
DG1/2564R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the recombinant DOG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant DOG1 antibody is available for research use only.
Storage Conditions
Store the recombinant DOG1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Cell Surface and Cytoplasmic
Image Legend
IHC testing of FFPE human gastrointestinal stromal tumor (GIST) with DOG1 antibody (clone DG1/2564R) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q5XXA6

Anoctamin-1

ANO1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q5XXA6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ANO1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A0A2H4Y9B2, A8KAM3, E9PNA7, Q8IYY8, Q8N7V3
Protein keywords

Coding sequence diversity

Alternative splicing

Ligand

CalciumChlorideMetal-binding

Cellular component

Cell membraneCell projectionMembraneSynapse

Molecular function

Chloride channelDevelopmental proteinIon channel

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Ion transportTransport

Technical term

Proteomics identificationReference proteome

Domain

TransmembraneTransmembrane helix

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