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VCAM-1 Antibody

CAT: 0800-V7162IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7162IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Vascular cell adhesion molecule-1 (VCAM-1), also called L1CAM and CD106, is important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. [UniProt]
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P19320
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein was used as the immunogen for the VCAM-1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CDLA106
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the VCAM-1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This VCAM-1 antibody is available for research use only.
Storage Conditions
Store the VCAM-1 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic, membrane
Image Legend
IHC testing of FFPE human tonsil with VCAM-1 antibody (clone CDLA106) .

UniProtKB · P19320

Vascular cell adhesion protein 1

VCAM1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P19320
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
VCAM1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
V-CAM 1, VCAM-1
EC number
—
Processing
Precursor
Secondary accessions
A8K6R7, B4DKS4, E9PDD1, Q6NUP8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell adhesion

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinUbl conjugation

Domain

Immunoglobulin domainRepeatSignalTransmembraneTransmembrane helix

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