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Insulin Antibody

CAT: 0800-V7133IHC-7MLSize: 7 mLDry Ice: NoHazardous: No
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CAT#:0800-V7133IHC-7MLSize:7 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. [RefSeq]
CAS Number
9007-83-4
Specifications
The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
UniProt
P01308
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant INS protein was used as the immunogen for the Insulin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
BCPH1
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*
Reconstitution
Store the Insulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Insulin antibody is available for research use only.
Storage Conditions
Store the Insulin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05% sodium azide; *For IHC use only*
Location
Cytoplasmic
Image Legend
IHC testing of FFPE human pancreas stained with Insulin antibody (clone BCPH1) .

UniProtKB · P01308

Insulin

INS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01308
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q5EEX2
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Carbohydrate metabolismGlucose metabolism

PTM

Cleavage on pair of basic residuesDisulfide bond

Disease

Diabetes mellitusDisease variant

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal
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