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Insulin Receptor Antibody

CAT: 0800-F50643-0.2MLSize: 0.2 mLDry Ice: NoHazardous: No
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CAT#:0800-F50643-0.2MLSize:0.2 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
INSR binds insulin and has a tyrosine-protein kinase activity. Autophosphorylation activates the kinase activity. This Type I mebrane protein is composed of a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain. After being transported from the endoplasmic reticulum to the Golgi apparatus, the single glycosylated precursor is further glycosylated and then cleaved, followed by its transport to the plasma membrane.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P06213
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 21-52 from the human protein was used as the immunogen for this Insulin Receptor antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
IHC, WB, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the Insulin Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Insulin Receptor antibody is available for research use only.
Storage Conditions
Aliquot the Insulin Receptor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the Insulin Receptor antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat
Image Legend
Western blot analysis of Insulin receptor antibody and SKBR-3 cell lysate. Expected size: ~156 kDa (precursor), ~95 kDa (b-subunit)

UniProtKB · P06213

Insulin receptor

INSR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06213
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INSR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
IR
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
Q17RW0, Q59H98, Q9UCB7, Q9UCB8, Q9UCB9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Carbohydrate metabolism

Cellular component

Cell membraneEndosomeLysosomeMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinIsopeptide bondPhosphoproteinS-nitrosylationUbl conjugation

Disease

Diabetes mellitusDisease variant

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

RepeatSignalTransmembraneTransmembrane helix

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