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Insulin / IRDN Antibody

CAT: 0800-V7885-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V7885-100UGSize:100 µg
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Description
Recognizes a polypeptide which is identified as insulin, a 51-amino acid polypeptide composed of A and B chains connected through the C-peptide. Proinsulin, which has very little biological activity, is cleaved by proteases within its cell of origin into the insulin molecule and the C-terminal basic residue. Insulin enhances membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides, and synthesis of proteins and nucleic acids. Deficiency of insulin results in diabetes mellitus. The main storage site for insulin is the pancreatic islets. Antibodies to insulin are important as beta-cell and insulinoma marker.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.1-0.2 µg/mL
UniProt
P01308
Host
Mouse
Reactivity
Human
Immunogen
Purified human insulin was used as the immunogen for the Insulin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
K36aC10
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Store the Insulin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Insulin antibody is available for research use only.
Storage Conditions
Store the Insulin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Insulin antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human pancreas with Insulin antibody (clone K36aC10) . No HIER required.

UniProtKB · P01308

Insulin

INS_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P01308
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
INS
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q5EEX2
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Carbohydrate metabolismGlucose metabolism

PTM

Cleavage on pair of basic residuesDisulfide bond

Disease

Diabetes mellitusDisease variant

Molecular function

Hormone

Cellular component

Secreted

Domain

Signal

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