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AURKB Antibody / Aurora B

CAT: 0800-V3927SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3927SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Aurora B is a serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. [UniProt]
CAS Number
9007-83-4
Specifications
IHC (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q96GD4
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 89-251 were used as the immunogen for this AURKB antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
ARRK2-1
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the AURKB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This AURKB antibody is available for research use only.
Storage Conditions
Store the AURKB antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the AURKB antibody should be determined by the researcher.
Location
Nuclear, cytoplasmic
Image Legend
IHC testing of FFPE human prostate tissue with AURKB antibody (clone ARRK2-1) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q96GD4

Aurora kinase B

AURKB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q96GD4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AURKB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.1
Processing
—
Secondary accessions
B4DNM4, C7G533, C7G534, C7G535, D3DTR4, J9JID1, O14630, O60446, O95083, Q96DV5, Q9UQ46
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingNucleotide-binding

Biological process

Cell cycleCell divisionMitosis

Cellular component

CentromereChromosomeCytoplasmCytoskeletonKinetochoreNucleus

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

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