Aurora B Antibody / AURKB

Aurora B Antibody / AURKB

• Description: Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.
• CAS Number: 9007-83-4
• UniProt: Q96GD4
• Host: Mouse
• Immunogen: A recombinant human protein fragment (amino acids 89-251) was used as the immunogen for this Aurora B antibody.
• Clonality: Monoclonal
• Isotype: IgG1 κ
• Applications: IHC-P
• Format: Purified
• Buffer: 1 mg/ml in 1X PBS; BSA free, sodium azide free
• Reconstitution: Store the Aurora B antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
• Limitations: This Aurora B antibody is available for research use only.