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CD11c Antibody

CAT: 0800-V3860-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3860-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a protein of 145kDa, identified as CD11c. CD11c (ITGAX), a member of the leukointegrin family, shares the same beta subunit with other members of the leukocyte adhesion molecule family, which includes CD11a (LFA-1), CD11b (MAC-1) and CD11d (ITGAD), but has a unique alpha chain. CD11c has been shown to play a role in phagocytosis, cell migration, and cytokine production by monocytes/macrophages as well as induction of T-cell proliferation by Langerhans cells. CD11c is expressed prominently on the plasma membranes of monocytes, tissue macrophages, NK cells, and most dendritic cells (DCs) . A lower level of expression is also observed on neutrophils as a result of its high level of expression on most DCs. An antibody to CD11c may aid in identification of lesions with histiocytic origin. It may also been used as a marker for hairy cell leukemia in paraffin-embedded tissues.
CAS Number
9007-83-4
Specifications
ELISA: 1-5 µg/mL for coating (order BSA/sodium azide-free format)
UniProt
P20702
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein (aa 637-827) was used as the immunogen for the CD11c antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ITGAX/2507
Applications
ELISA
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD11c antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD11c antibody is available for research use only.
Storage Conditions
Store the CD11c antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD11c antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
IHC testing of FFPE human tonsil with CD11c antibody (clone ITGAX/2507) . Required HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

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