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Itgax Antibody / Cd11c

CAT: 0800-RQ6137Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6137Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a genethat encodes for CD11c. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4) . The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
Q9QXH4
Host
Rabbit
Reactivity
Mouse
Immunogen
A mouse recombinant partial protein (amino acids F20-E332) was used as the immunogen for the Itgax antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS, Direct ELISA
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Itgax antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Itgax antibody is available for research use only.
Storage Conditions
After reconstitution, the Itgax antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Itgax antibody should be determined by the researcher.
Image Legend
Flow cytometry testing of mouse spleen cells with Itgax antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= Itgax antibody.

UniProtKB · Q9QXH4

Integrin alpha-X

ITAX_MOUSE · Mus musculus

View on UniProt ↗
Primary accession
Q9QXH4
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Itgax
Protein existence
1: Evidence at protein level
Organism
Mus musculus (Mouse)
Taxonomy ID
10090
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
—
Protein keywords

Ligand

CalciumMagnesiumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Molecular function

IntegrinReceptor

Technical term

Reference proteome

Domain

RepeatSignalTransmembraneTransmembrane helix
Product Datasheet
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