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OLIG2 Antibody

CAT: 0800-V3822-20UGSize: 20 µgDry Ice: NoHazardous: No
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CAT#:0800-V3822-20UGSize:20 µg
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Description
Olig2, a basic helix-loop-helix transcription factor, is involved in oligodendroglial specification. Olig2 expression has been reported in most glial tumors, such as oligodendrogliomas and astrocytomas. Although more than half of glioblastomas are positive for Olig2, expression is very weak in terms of both percentage of labeled cells and intensity. No Olig2 expression has been found in the non-glial tumors including neuro-epithelial tumors, ependymomas, sub-ependymomas, medulloblastomas, and non-neuroepithelial tumors, such as CNS lymphomas, meningiomas, schwannomas, atypical teratoid / rhabdoid tumor, and haemangioblastomas. Compared to the strong staining seen in glioma samples, a weak expression is observed in non-tumoral brain tissue (gliosis) .
CAS Number
9007-83-4
Specifications
IHC (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q13516
Host
Mouse
Reactivity
Human
Immunogen
A portion of amino acids 1-141 from the human protein was used as the immunogen for this OLIG2 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
ODTF2-1
Applications
IHC-P
Purity
Protein G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
After reconstitution, the OLIG2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This OLIG2 antibody is available for research use only.
Storage Conditions
After reconstitution, the OLIG2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the OLIG2 antibody should be determined by the researcher.
Location
Nuclear
Image Legend
IHC testing of FFPE human cerebellum with OLIG2 antibody (clone ODTF2-1) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · Q13516

Oligodendrocyte transcription factor 2

OLIG2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13516
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
OLIG2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Oligo2
EC number
—
Processing
—
Secondary accessions
B3KRF3, Q05BP9, Q49AL3, Q86X04, Q9NZ14
Protein keywords

Coding sequence diversity

Chromosomal rearrangement

Cellular component

CytoplasmNucleus

Molecular function

Developmental proteinDNA-binding

Technical term

Proteomics identificationReference proteome

Disease

Proto-oncogene

Biological process

TranscriptionTranscription regulation

PTM

Ubl conjugation

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CatalogName
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