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Cyclin A2 Antibody / CCNA2

CAT: 0800-V3780SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3780SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This antibody recognizes a protein of 50-55 kDa, which is identified as Cyclin A. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, Cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while Cyclin B is a critical regulator of mitosis. Mutation or disruption of normal Cyclin A expression causes cells to arrest in G2-phase.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P20248
Host
Mouse
Reactivity
Human
Immunogen
Full length protein was used as the immunogen for this CCNA2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
CCNA2/2333
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Cyclin A2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Cyclin A2 antibody is available for research use only.
Storage Conditions
Store the Cyclin A2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the Cyclin A2 antibody to be titered up or down for optimal performance.
Location
Nuclear, cytoplasmic
Image Legend
IHC testing of FFPE human endometrial carcinoma with Cyclin A2 antibody. Required HIER: steam section in pH6 citrate buffer for 20 min and allow to cool prior to staining.

UniProtKB · P20248

Cyclin-A2

CCNA2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P20248
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CCNA2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Cyclin-A
EC number
—
Processing
—
Secondary accessions
A8K7B6, Q2M3U6, Q4W5P4, Q6LER8
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoproteinUbl conjugation

Biological process

Cell cycleCell divisionHost-virus interactionMitosis

Molecular function

Cyclin

Cellular component

CytoplasmNucleus

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