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Recombinant SOX10 Antibody

CAT: 0800-V3777SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3777SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. It may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. [RefSeq]
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
UniProt
P56693
Host
Rabbit
Reactivity
Human
Immunogen
Amino acids 115-269 of the human protein were used as the immunogen for the recombinant SOX10 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
SBX10-2R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant SOX10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant SOX10 antibody is available for research use only.
Storage Conditions
Store the recombinant SOX10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Nuclear
Image Legend
IHC staining of FFPE human melanoma tissue with recombinant SOX10 antibody (clone SBX10-2R) . Required HIER: boil sections in pH 9 10mM Tris with 1mM EDTA for 10-20 minutes, followed by cooling at RT for 20 minutes, prior to staining.

UniProtKB · P56693

Transcription factor SOX-10

SOX10_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P56693
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SOX10
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B4DV62, Q6FHW7
Protein keywords

Molecular function

ActivatorDNA-binding

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membraneNucleus

Disease

DeafnessDisease variantHirschsprung diseaseKallmann syndromeWaardenburg syndrome

PTM

Phosphoprotein

Technical term

Proteomics identificationReference proteome

Biological process

TranscriptionTranscription regulation

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