SOX10 Antibody

CAT: 0800-V3507-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V3507-20UGSize:20 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
This mAb recognizes a protein of ~50 kDa identified as SOX10. This mAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P56693
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Amino acids 115-269 of the human protein were used as the immunogen for the SOX10 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
SOX10/991
Applications
WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the SOX10 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This SOX10 antibody is available for research use only.
Storage Conditions
Store the SOX10 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the SOX10 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Location
Nuclear

Related Products

CatalogName
RZ1116Zebrafish Sox1 Antibody / Sox1a / Sox1b
R33339-100UGSOX15 Antibody
V4834SAF-100UGSOX18 Antibody
V4834-20UGSOX18 Antibody
F52803-0.08MLSox17 Antibody
RQ6577Sox11 Antibody
F44542-0.08MLSOX11 Antibody
F52803-0.4MLSox17 Antibody
RQ6340SOX18 Antibody
R36049-100UGSOX11 Antibody

Alternative Products

CatalogName
33-851SOX10 Antibody [SOX10/991]
33-853SOX10 Antibody [SOX10/1074]
MBS8517295-01SOX10 Antibody

Popular Products