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CDC2 Antibody / CDK1

CAT: 0800-V3748-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3748-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Recognizes a 34kDa protein (cdk1), identified as Cdk1/Cdc2/p34cdc2 (a catalytic subunit of Maturation Promoting Factor) . Its epitope maps near the C-terminus of the protein and its core is thought to be LGTPNNEV (aa220-227 in murine cdc2) . It shows no cross reaction with cdk2 p32. It supports the kinase activity. p34cdc2 plays a crucial role during cell division and is most active during mitosis. It is a serine/threonine kinase, which is activated by cyclin, by dephosphorylation of tyrosine residues. p34cdc2 is inactivated by a tyrosine kinase. This mAb reportedly inhibits the activation of p34cdc2 kinase by cyclins.
CAS Number
9007-83-4
Specifications
Inhibits activation of p34cdc2 kinase by cyclins, Immunofluorescence: 1-2 µg/mL, Immunoprecipitation, Kinase assay, Western blot, Immunohistochemistry (FFPE) : 2-4 µg/mL for 30 min at RT
UniProt
P06493
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A partial protein (the C-terminal two-thirds of Xenopus CDC2) was used as the immunogen for this CDC2 antibody.
Clonality
Monoclonal
Isotype
IgG2a κ
Clone
A17.1.1
Applications
Inhibition, IF, IP, Kinase assay, WB, IHC-P
Purity
Protein G purified antibody
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CDC2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CDC2 antibody is available for research use only.
Storage Conditions
Store the CDC2 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Location
Nuclear and Cytoplasmic
Image Legend
IHC staining of FFPE human tonsil with CDC2 antibody (clone A17.1.1) . HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

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