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Recombinant MMP3 Antibody

CAT: 0800-V3642SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3642SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB) . MMP catalysis requires both calcium and zinc. MMP3, MMP10 and MMP11 (also designated stromelysin-1, 2 and 3, respectively) activate procollagenase. MMP3 activation of procollagenase can occur via two pathways. Direct activation by MMP3 is slow and activation by MMP3 in conjunction with tissue or plasma proteinases is rapid. MMP10 is expressed in small intestine, and at lower levels in lung and heart. MMP11 is specifically expressed in stromal cells of breast carcinomas and contributes to epithelial cell malignancies.
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08254
Host
Mouse
Reactivity
Human
Immunogen
Amino acids 317-327 were used as the immunogen for the recombinant MMP3 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RMMP3/1730
Type
Recombinant
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the recombinant MMP3 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This recombinant MMP3 antibody is available for research use only.
Storage Conditions
Store the recombinant MMP3 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Location
Cytoplasmic, secreted
Image Legend
IHC testing of FFPE human placenta with recombinant MMP3 antibody (clone rMMP3/1730) . Required HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P08254

Stromelysin-1

MMP3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08254
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MMP3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SL-1
EC number
3.4.24.17
Processing
Precursor
Secondary accessions
B2R8B8, Q3B7S0, Q6GRF8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Biological process

Collagen degradationImmunityInnate immunity

Cellular component

CytoplasmExtracellular matrixNucleusSecreted

PTM

Disulfide bondZymogen

Molecular function

HydrolaseMetalloproteaseProtease

Domain

RepeatSignal

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