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Recombinant MMP3 Antibody

CAT: 0013-GTR18082194-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18082194-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The MMP3 gene encodes the enzyme Stromelysin-1, which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [RefSeq]
UniProt
P08254
Reactivity
Human
Immunogen
Amino acids 317-327 were used as the immunogen for the recombinant MMP3 antibody.
Clonality
Recombinant
Clone
MXMP3-1R
Conjugation
Unconjugated
Field of Research
Immunology & Inflammation
Purification
Protein G affinity chromatography
Dilution
Immunohistochemistry (FFPE) : 1-2ug/ml for 30 min at RT, Prediluted IHC only format: incubate for 30 min at RT (1)
Storage Conditions
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Notes
For research use only.
Applications Notes
Optimal dilution of the recombinant MMP3 antibody should be determined by the researcher.1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.
Tested Applications
IHC-P
Host or Source
Mouse
Preservative
0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin and 0.05% sodium azide
Isotype
Mouse IgG1, kappa

UniProtKB · P08254

Stromelysin-1

MMP3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08254
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
MMP3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SL-1
EC number
3.4.24.17
Processing
Precursor
Secondary accessions
B2R8B8, Q3B7S0, Q6GRF8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-bindingZinc

Biological process

Collagen degradationImmunityInnate immunity

Cellular component

CytoplasmExtracellular matrixNucleusSecreted

PTM

Disulfide bondZymogen

Molecular function

HydrolaseMetalloproteaseProtease

Domain

RepeatSignal

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