NSE Antibody / Neuron Specific Enolase

• Description:

  This mAb recognizes a protein of about 50 kDa which is identified as gamma-Enolase/Neuron Specific Enolase/Enolase 2. Three isoenzymes of enolases are identified, alpha, beta and gamma. Alpha-isoform is expressed in most tissues, whereas beta-form is expressed predominantly in muscle tissue and gamma-enolase is found only in nervous tissue. These isoforms exist as both homodimers and heterodimers, and they play a role in converting phosphoglyceric acid to phosphenolpyruvic acid in the glycolytic pathway. NSE is a useful marker to identify peripheral nerves and tumors of neuro-endocrine origins, such as pheochromocytomas. It it be usually employed in combination with other markers such as Synaptophysin, Chromogranin A, and Neurofilament.

• UniProt:

  P09104

• Host:

  Mouse

• Immunogen:

  Amino acids 416-433 of human NSE were used as the immunogen for this Neuron Specific Enolase antibody.

• Clonality:

  Monoclonal

• Isotype:

  IgG2b κ

• Applications:

  IHC-P

• Format:

  Purified

• Buffer:

  Prediluted in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide; *For IHC use only*

• Reconstitution:

  Store the Neuron Specific Enolase antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

• Limitations:

  This Neuron Specific Enolase antibody is available for research use only.

• CAS Number:

  9007-83-4