CD81 Antibody

CAT: 0800-V3485-20UGSize: 20 µgDry Ice: NoHazardous: No
CAT#:0800-V3485-20UGSize:20 µg
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Description
This mAb recognizes a protein of 26kDa, identified as CD81 (Workshop VI; Code CD81.1) . CD81 has a very broad cellular distribution, being expressed on T- and B-lymphocytes, NK cells, thymocytes, eosinophils, fibroblasts, epithelial and endothelial cells. Neutrophils, erythrocytes and platelets are negative, while monocytes are variably positive. CD81 is a member of a family of tetraspans transmembrane proteins, including CD9, CD37, CD53, CD63, and CD82. It associates with CD19, CD21, Leu 13, and integrins on cell membrane and is involved in signal transduction in B lymphocyte development and cell adhesion. CD81 also acts as a receptor for the envelope protein E2 of chronic hepatitis C virus. Antibodies to CD81 have anti-proliferative effects on different lymphoid cell lines, particularly those derived from large cell lymphomas.
CAS Number
9007-83-4
Specifications
Functional studies: order BSA/sodium azide-free format, Flow cytometry: 0.5-1ug/million cells, Immunofluorescence: 0.5-1 µg/mL, Western blot: 0.5-1 µg/mL for 2 hours at RT, Immunohistochemistry (FFPE) : 2-4 µg/mL for 30 min at RT
UniProt
P60033
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full length human protein was used as the immunogen for the CD81 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
1.3.3.22
Applications
Functional studies, FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the CD81 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This CD81 antibody is available for research use only.
Storage Conditions
Store the CD81 antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the CD81 antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
IHC testing of FFPE human tonsil with CD81 antibody (clone 1.3.3.22) . Required HIER: boil tissue sections in 10mM citrate buffer, pH 6, for 10-20 min followed by cooling at RT for 20 min.

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