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Podoplanin Antibody

CAT: 0800-V3404SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3404SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Podoplanin (PDPN) is a muco-protein which localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. It is selectively expressed in lymphatic endothelium as well as lymphoangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. Recent studies have also shown podoplanin to be a highly sensitive and relatively specific marker for epithelioid mesothelioma. Therefore, it can be used in a panel to distinguish mesotheliomas or mesothelial cells from pulmonary carcinomas.
CAS Number
9007-83-4
Specifications
ELISA (order BSA/sodium azide-free format for coating), Immunofluorescence: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q86YL7
Host
Mouse
Reactivity
Human
Immunogen
A human recombinant partial protein corresponding to amino acids 24-126 was used as the immunogen for the Podoplanin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PDPN/1433
Applications
ELISA, IF, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the Podoplanin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Podoplanin antibody is available for research use only.
Storage Conditions
Store the Podoplanin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Podoplanin antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic
Image Legend
Analysis of HuProt (TM) microarray containing more than 19,000 full-length human proteins using Podoplanin antibody (clone PDPN/1433) . These results demonstrate the foremost specificity of the PDPN/1433 mAb. Z- and S- score: The Z-score represents the strength of a signal that an antibody (in combination with a fluorescently-tagged anti-IgG secondary Ab) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If the targets on the HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-scores. The S-score therefore represents the relative target specificity of an Ab to its intended target.
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