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B-Catenin Antibody

CAT: 0800-V3250SAF-100UGSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-V3250SAF-100UGSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Beta Catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. In Drosophila, the homologous protein is called armadillo. b-Catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to gamma-Catenin, also known as plakoglobin. b-Catenin is widely expressed in many tissues. In cardiac muscle, it localizes to adherens junctions in intercalated disc structures, which are critical for electrical and mechanical coupling between adjacent cardiomyocyte. [Wiki]
CAS Number
9007-83-4
Specifications
Flow cytometry: 0.5-1ug/10^6 cells, Immunofluorescence: 1-2 µg/mL, Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P35222
Host
Mouse
Reactivity
Human
Immunogen
Chicken beta-Catenin was used as the immunogen for the b-Catenin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
6F9
Applications
FACS, IF, WB, IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Store the b-Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This b-Catenin antibody is available for research use only.
Storage Conditions
Store the b-Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the b-Catenin antibody to be determined by the researcher.
Location
Cell surface, cytoplasmic, cell junctions
Image Legend
IHC testing of FFPE human tonsil tissue with b-Catenin antibody (clone 6F9) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.

UniProtKB · P35222

Catenin beta-1

CTNB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35222
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTNNB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K1L7, Q8NEW9, Q8NI94, Q9H391
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

Activator

Biological process

Cell adhesionHost-virus interactionNeurogenesisTranscriptionTranscription regulationWnt signaling pathway

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleusSynapse

Coding sequence diversity

Chromosomal rearrangement

Disease

Disease variantIntellectual disability

Domain

Repeat
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