Products for Research Use Only
RegisterLogin

Beta Catenin Antibody

CAT: 0800-V3243-20UGSize: 20 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0800-V3243-20UGSize:20 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Beta-Catenin associates with the cytoplasmic portion of E-Cadherin, which is necessary for the function of E-Cadherin as an adhesion molecule. In normal tissues, beta-Catenin is localized to the membrane of epithelial cells, consistent with its role in the cell adhesion complex. In breast ductal neoplasia, beta-catenin is usually localized in cellular membranes. However, in lobular neoplasia, a marked redistribution of beta-Catenin throughout the cytoplasm results in a diffuse cytoplasmic pattern. Immunostaining of beta-Catenin and E-Cadherin is helps in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 0.1-0.2 µg/mL for 30 min at RT
UniProt
P35222
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
A partial human recombinant protein was used as the immunogen for the Beta Catenin antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
CTNNB1/1508
Applications
IHC-P
Purity
Protein G affinity chromatography
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide
Reconstitution
Store the Beta Catenin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).
Limitations
This Beta Catenin antibody is available for research use only.
Storage Conditions
Store the Beta Catenin antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide) .
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05% sodium azide
Applications Notes
Optimal dilution of the Beta Catenin antibody to be determined by the researcher.
Location
Cell surface, cytoplasmic, cell junctions
Image Legend
IHC testing of FFPE human pancreas tissue with Beta Catenin antibody (clone CTNNB1/1508) . Required HIER: boil tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 10-20 min.

UniProtKB · P35222

Catenin beta-1

CTNB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35222
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTNNB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K1L7, Q8NEW9, Q8NI94, Q9H391
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

Activator

Biological process

Cell adhesionHost-virus interactionNeurogenesisTranscriptionTranscription regulationWnt signaling pathway

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleusSynapse

Coding sequence diversity

Chromosomal rearrangement

Disease

Disease variantIntellectual disability

Domain

Repeat

Related Products

CatalogName
V4976-20UGCatenin Beta Antibody / CTNNB1
V4977SAF-100UGCTNNB1 Antibody / Catenin Beta
V8478-20UGRecombinant Catenin beta Antibody
V4976SAF-100UGCatenin Beta Antibody / CTNNB1
V4976-100UGCatenin Beta Antibody / CTNNB1
V8478-100UGRecombinant Catenin beta Antibody
V8966-100UGRecombinant Catenin Beta Antibody
F54317-0.4MLCatenin Beta Antibody / CTNNB1
V4977-100UGCTNNB1 Antibody / Catenin Beta
V8966SAF-100UGRecombinant Catenin Beta Antibody

Alternative Products

CatalogName
MBS2169924-01Monoclonal Antibody to Beta Catenin (beta-catenin)
TRV-022403-01Monoclonal Antibody to Beta Catenin (β-catenin)
MBS9527332-01Beta-catenin (ABT-Catenin) Antibody
CAU35181-01Beta Catenin (β-catenin) Monoclonal Antibody
CAU26655-01Beta Catenin (β-catenin) Polyclonal Antibody
TRV-002696-01Polyclonal Antibody to Beta Catenin (β-catenin)
MBS2111494-01Anti-Beta Catenin (beta-catenin) Polyclonal Antibody
053169β-catenin (Beta Catenin)
144285Catenin beta, CT (Beta-catenin)
MBS2122745-01Recombinant Beta Catenin (beta-catenin)

Popular Products