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Beta Catenin Antibody

CAT: 0800-RQ4508Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4508Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as alpha-catenin and beta-catenin. Alpha-catenin can bind to beta-catenin and can also bind actin. Beta-catenin binds the cytoplasmic domain of some cadherins. Beta-catenin is an adherens junction protein. It plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy. HGF-induced hepatpomegaly, liver zonation, and pathogenesis of liver cancer.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL, Immunocytochemistry: 2-4 µg/mL, Immunofluorescence: 2-4 µg/mL, FACS: 1-3ug/million cells
UniProt
P35222
Host
Mouse
Reactivity
Human
Immunogen
Human beta Catenin recombinant protein (amino acids A2-K233) was used as the immunogen for the Beta Catenin antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
1F6
Applications
WB, IHC-P, ICC, IF, FACS
Purity
Protein G affinity
Format
Purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose and 0.025% sodium azide
Reconstitution
After reconstitution, the Beta Catenin antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This Beta Catenin antibody is available for research use only.
Storage Conditions
After reconstitution, the Beta Catenin antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the Beta Catenin antibody should be determined by the researcher.
Location
Cell surface, cytoplasmic, cell junctions, nuclear
Image Legend
Immunofluorescent testing of FFPE human A431 cells with Beta Catenin antibody. HIER: boil tissue sections in pH6, 10mM citrate buffer, for 10-20 min followed by cooling at RT for 20 min.

UniProtKB · P35222

Catenin beta-1

CTNB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P35222
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CTNNB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K1L7, Q8NEW9, Q8NI94, Q9H391
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationGlycoproteinPhosphoproteinS-nitrosylationUbl conjugation

Molecular function

Activator

Biological process

Cell adhesionHost-virus interactionNeurogenesisTranscriptionTranscription regulationWnt signaling pathway

Cellular component

Cell junctionCell membraneCell projectionCytoplasmCytoskeletonMembraneNucleusSynapse

Coding sequence diversity

Chromosomal rearrangement

Disease

Disease variantIntellectual disability

Domain

Repeat

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